Plant Transcription Factor Database
Previous version: v3.0
Arabidopsis thaliana
SRS Family
Species TF ID Description
AT1G19790.1SHI-related sequence 7
AT1G19790.2SHI-related sequence 7
AT1G75520.1SHI-related sequence 5
AT2G18120.1SHI-related sequence 4
AT2G21400.1SHI-related sequence3
AT3G51060.1Lateral root primordium (LRP) protein-related
AT3G54430.1SHI-related sequence 6
AT4G36260.1Lateral root primordium (LRP) protein-related
AT5G12330.1Lateral root primordium (LRP) protein-related
AT5G12330.2Lateral root primordium (LRP) protein-related
AT5G12330.3Lateral root primordium (LRP) protein-related
AT5G12330.4Lateral root primordium (LRP) protein-related
AT5G33210.1SHI-related sequence 8
AT5G33210.2SHI-related sequence 8
AT5G66350.1Lateral root primordium (LRP) protein-related
SRS Family Introduction

SHI RELATED SEQUENCE(SRS), which encode proteins with a single zinc finger motif. The genes are members of a small gene family of putative transcription factors in which the SHORT INTERNODES (SHI) gene is found.

The predicted amino acid sequence of SHI has acidic and glutamine-rich stretches and shows sequence similarity over a putative zinc finger region to three presumptive Arabidopsis proteins. This suggests that SHI may act as a negative regulator of GA responses through transcriptional control.

The predicted SHI protein consists of 331 amino acids. A region containing six cysteine residues (amino acids 120 to 147) in a C-X2-C-X7-C-X4-C-X2-C-X7-C arrangement (where X is a variable amino acid) is suggested to make up a zinc finger domain similar to the Zn2Cys6 cluster found in the DNA binding region of the yeast transcriptional activator GAL4 (Kraulis et al. 1992 ). Two regions rich in glutamine residues were found adjacent to the zinc finger domain, as well as a short stretch of acidic residues in the C-terminal third of the SHI protein. These features have been found in transcription factor proteins and have been demonstrated to be important for their function as transcriptional activators (Mitchell and Tjian 1989 ). Furthermore, two putative nuclear localization signals (NLSs) were found in the SHI sequence. These are two basic stretches (amino acids 160 to 165 and 183 to 188) that conform to the consensus of the simian virus 40ĘClike "typical NLS" defined as four arginines and lysines within a region of six amino acids (Boulikas 1994 ; LaCasse and Lefebvre 1995 ).

Fridborg I, Kuusk S, Moritz T, Sundberg E.
The Arabidopsis dwarf mutant shi exhibits reduced gibberellin responses conferred by overexpression of a new putative zinc finger protein.
Plant Cell. 1999 Jun;11(6):1019-32.